99.REGARDING LIPOPROTEIN LIPASE ALL ARE TRUE EXCEPT
A.LOCATED ON ENDOTHELIAL CELLS OF CAPILLARIES
B.HYDROLYSE CHYLOMICRONS AND VLDL
C.APO-CII ACTS AS CO FACTOR
D. RELEASED BY ADMINISTRATION OF HEPARIN
ANS:RELEASED BY ADMINISTRATION OF HEPARIN
LPL isozymes are regulated differently depending on the tissue. For example, insulin is known to activate LPL in adipocytes and its placement in the capillary endothelium.The form that is in adipocytes is activated by insulin, whereas that in muscle and myocardium is activated by glucagon and adrenaline. This helps to explain why during fasting, LPL activity increases in muscle tissue and decreases in adipose tissue. After feasting, the opposite occurs
Lipoprotein lipase (LPL) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires Apo-CII as a cofactor.
LPL is attached to the luminal surface of endothelial cells in capillaries. It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands.
A.LOCATED ON ENDOTHELIAL CELLS OF CAPILLARIES
B.HYDROLYSE CHYLOMICRONS AND VLDL
C.APO-CII ACTS AS CO FACTOR
D. RELEASED BY ADMINISTRATION OF HEPARIN
ANS:RELEASED BY ADMINISTRATION OF HEPARIN
LPL isozymes are regulated differently depending on the tissue. For example, insulin is known to activate LPL in adipocytes and its placement in the capillary endothelium.The form that is in adipocytes is activated by insulin, whereas that in muscle and myocardium is activated by glucagon and adrenaline. This helps to explain why during fasting, LPL activity increases in muscle tissue and decreases in adipose tissue. After feasting, the opposite occurs
Lipoprotein lipase (LPL) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires Apo-CII as a cofactor.
LPL is attached to the luminal surface of endothelial cells in capillaries. It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands.
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