Monday 25 June 2012

103.MITOTIC INHIBITOR THAT BINDS WITH TUBULIN AND INHIBITS CELL CYCLE

A.VINKA ALKALOIDS
B.ANTIMETABOLITES
C.ANTIBIOTICS
D,

ANS:VINKA ALKALOIDS


Vinca alkaloids are a set of anti-mitotic and anti-microtubule agents that were originally derived from the Periwinkle plant Catharanthus roseus.

Vinca alkaloids are used in the treatment of cancer. They are a class of cell-cycle-specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting upon tubulin, they prevent it from forming into microtubules, a necessary component for cellular division.

Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These compounds include vinblastine, vincristine, vindesine, and vinorelbine.

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