147.WALDENSTORM MACROGLOBULINEMIA ASSOCIATED WITH
A.IgG
B.IgD
C.IgM
D.IgA
ANS:IgM
Waldenström's macroglobulinaemia (WM) is a rare chronic B-cell lymphoproliferative disorder characterised by a monoclonal immunoglobulin M (IgM) paraprotein and morphological evidence of lymphoplasmacytic lymphoma. The clinical manifestations are caused by direct organ tumour infiltration and hyperviscosity.1 It is regarded as a low-grade non-Hodgkin's lymphoma. The overproduction of IgM causes hyperviscosity of blood, interfering with circulation through small blood vessels.
Diagnostic criteria for WM are:
IgM monoclonal gammopathy of any concentration.
Bone marrow infiltration by small lymphocytes showing plasmacytoid or plasma cell differentiation.
Intertrabecular pattern of bone marrow infiltration.
Surface IgM+ CD5- CD10- CD19+ CD20+ CD22+ CD23- CD25+ CD27+ FMC7+ CD103- CD138- immunophenotype.
A.IgG
B.IgD
C.IgM
D.IgA
ANS:IgM
Waldenström's macroglobulinaemia (WM) is a rare chronic B-cell lymphoproliferative disorder characterised by a monoclonal immunoglobulin M (IgM) paraprotein and morphological evidence of lymphoplasmacytic lymphoma. The clinical manifestations are caused by direct organ tumour infiltration and hyperviscosity.1 It is regarded as a low-grade non-Hodgkin's lymphoma. The overproduction of IgM causes hyperviscosity of blood, interfering with circulation through small blood vessels.
Diagnostic criteria for WM are:
IgM monoclonal gammopathy of any concentration.
Bone marrow infiltration by small lymphocytes showing plasmacytoid or plasma cell differentiation.
Intertrabecular pattern of bone marrow infiltration.
Surface IgM+ CD5- CD10- CD19+ CD20+ CD22+ CD23- CD25+ CD27+ FMC7+ CD103- CD138- immunophenotype.
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